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Laboratory factors can also affect results, including assay interference (macro-B12) and variations in reference ranges between laboratories

Carbon monoxide (CO) levels are high in CS and CO is a known inhibitor of heme-containing enzymes such as the cytochrome P450s [30] and mitochondrial complexes [31]

Ten trials 13,14,2632 had sufficient data for the meta-analysis (n=366 treatment, n=359 control), and five trials 15,26,3335 were excluded from quantitative synthesis due to incomplete or non-extractable data

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